EVALUATION OF THE ACUTE AND CHRONIC TOXICITY OF THE ETHANOLIC EXTRACT OF ABELMOSCHUS ESCULENTUS INSWISS ALBINO MICE

Objectives: This work aimed to evaluate the acute and chronic toxicity of ethanolic extract Abelmoschus esculentus, administered orally Swiss albino mice. Methods: An dosage 2000 mg/kg was administrated studies were conducted following organization for economic cooperation development guidelines 425 407 respectively in During study, general signs monitored. The mice which are used toxicology study sacrificed, histological, hematological, biochemical analyses done. Results: No behavioral changes observed all subjected study. did not bring about any deaths after 14 days doses also 90 at a very high days. Although significant variation hematocrit, granulocyte, lymphocyte, Alanine transaminase, total cholesterol levels, blood glucose have effect (p<0.05) on other hematological parameters evaluated during Conclusion: result indicates that oral administration A. esculentus produce toxic Hence, can be utilized safely therapeutic use pharmaceutical formulations.